Phenotypes Associated with This Genotype

Genotype
MGI:5286555

• Allelic Composition: Ins2^Akita/Ins2^Akita; Ldlr^tm1Her/Ldlr^tm1Her
• Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:174983 )

• compared with Ldlr^tm1Her homozygotes

homeostasis/metabolism

hyperglycemia ( J:174983 )

• severe compared with Ldlr^tm1Her homozygotes

decreased circulating insulin level ( J:174983 )

• in fasting mice compared with Ldlr^tm1Her homozygotes

increased circulating cholesterol level ( J:174983 )

• in fasting mice compared with Ldlr^tm1Her homozygotes

increased circulating HDL cholesterol level ( J:174983 )

• in female mice compared with Ldlr^tm1Her homozygotes

increased circulating LDL cholesterol level ( J:174983 )

• 2-fold in male mice and 24% in female mice compared with Ldlr^tm1Her homozygotes

increased circulating VLDL cholesterol level ( J:174983 )

• 7-fold in male mice and 1.8-fold in female mice compared with Ldlr^tm1Her homozygotes

increased circulating triglyceride level ( J:174983 )

• in fasting mice compared with Ldlr^tm1Her homozygotes

impaired glucose tolerance ( J:174983 )

• compared with Ldlr^tm1Her homozygotes

growth/size/body

decreased body weight ( J:174983 )

• in male, but not female, mice at 20 weeks of age compared with Ldlr^tm1Her homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:174983 )

• accelerated in mice fed a high-fat diet compared with similarly treated Ldlr^tm1Her homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diabetic angiopathy		DOID:11713		J:174983