Phenotypes Associated with This Genotype

Genotype
MGI:5287987

hm4

• Allelic Composition: Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:175535 )

• size of the dopaminergic neuron progenitor domain is reduced

• remaining progenitors are mainly located in the medially

decreased motor neuron number ( J:175535 )

• almost complete loss of ocular motor neurons at E12.5

decreased neuronal precursor cell number ( J:175535 )

• size of the dopaminergic neuron (DN) progenitor domain is reduced

• remaining DN progenitors are mainly located in the medially

• most DN progenitor cells fail to initiate expression of late DN markers

increased neuron number ( J:175535 )

• increase in the number of red nucleus neurons at E12.5