Analysis Tools
cardiovascular system
|
• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion
• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%
• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants
|
embryo
|
• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion
• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%
• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants
|
endocrine/exocrine glands
 |
• females exhibit severe ovarian defects
|
reproductive system
|
|
• females exhibit severe ovarian defects
|
|
|
• homozygous mothers mated with homozygous males exhibit a loss of embryos as early as E9.5, with 54% resorption between E11.5 and E14.5
• homozygous mothers mated with heterozygous males and heterozygous mothers mated with homozygous males exhibit a similar loss of both heterozygous and homozygous embryos, indicating that lethality is not due to maternal factors and is correlated with the presence of homozygous embryos rather than the genotype of individual embryos
• homozygous mothers have fewer implantation sites than controls
|
growth/size/body
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pre-eclampsia | DOID:10591 |
OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 |
J:173527 | |
