Analysis Tools
cardiovascular system
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• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age
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cellular
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• mice fed doxycycline exhibit swollen cardiac mitochondria, which displace neighboring myofibrils
• some mitochondria in the soleus of doxycline-treated mice form whorls, which line the inner membrane wall
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• mice fed doxycycline exhibit an absence of tetralinoeoyl-cardiolipin in cardiac samples
• mice fed doxycycline exhibit a reduction in total cardiolipin and significant accumulation of monolyso-cardiolipin at 2 months
• mice fed doxycycline exhibit an increase in monolyso-cardiolipin/cardiolipin ratio at 2 months
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muscle
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• mice fed doxycycline exhibit a 20% decrease in left cardiac ventricular ejection fraction at both 7 and 10 months of age
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• skeletal muscle of doxycline-treated mice exhibits a reduction in soleus contractile strength when stimulated at >100 Hz
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Barth syndrome | DOID:0050476 |
OMIM:302060 |
J:176041 | |
