Phenotypes Associated with This Genotype

Genotype
MGI:5291505

• Allelic Composition: Del(7Slx1b-Sept1)4Aam/+
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:176335 )

• some mice die between birth and weaning

behavior/neurological

hyperactivity ( J:176335 )

• after habituation, mice exhibit a second burst of activity (walking and rearing) unlike control mice

• mice spend less time resting than control mice

• mice are more active in the dark and light phases compared with control mice

• mice exhibit a higher ratio of light to dark activity compared with control mice

increased locomotor activity ( J:176335 )

• mice exhibit higher distance traveled, time spent walking, and time spent lingering compared with control mice

stereotypic behavior ( J:176335 )

• mice exhibit extremely stereotypic ceiling-climbing unlike control mice with some mice becoming trapped on the ceiling for extensive periods

nervous system

abnormal hypothalamus morphology ( J:176335 )

• in the posterior, lateral regions compared with Dp(7Slx1b-Sept1)5Aam mice

hypothalamus hyperplasia ( J:176335 )

• in the lateral hypothalamus

growth/size/body

decreased body size ( J:176335 )

• prior to weaning but not as adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:176335