Phenotypes Associated with This Genotype

Genotype
MGI:5292519

• Allelic Composition: Zdhhc17^{Gt(RRJ233)Byg}/Zdhhc17^{Gt(RRJ233)Byg}
• Genetic Background: FVB.129P2-Zdhhc17^{Gt(RRJ233)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:175800 )

• in the striatum at E14.5

decreased brain weight ( J:175800 )

• at 1, 3, and 12 months of age

abnormal brain white matter morphology ( J:175800 )

• decreased volume without a change in microglial or astrocyte numbers

abnormal striatum morphology ( J:175800 )

• non-progressive reduction observed as early as E17.5

• at E14.5, cell death in the striatum is increased compared to in wild-type mice

• however, striatum volume at E14.5 is normal

decreased striatum size ( J:175800 )

• non-progressive reduction observed as early as E17.5

decreased hippocampus volume ( J:175800 )

• decreased volume

abnormal cerebral cortex morphology ( J:175800 )

• decreased volume

decreased neuron number ( J:175800 )

• of medium spiny neurons

abnormal synapse morphology ( J:175800 )

• medium spiny neurons contain fewer total and excitatory synapses in the striata compared to in wild-type mice

decreased prepulse inhibition ( J:175800 )

behavior/neurological

impaired coordination ( J:175800 )

• on a accelerating or fixed rotarod

impaired swimming ( J:175800 )

• swim speed is reduced compared to in wild-type mice

hyperactivity ( J:175800 )

increased vertical activity ( J:175800 )

increased horizontal stereotypic behavior ( J:175800 )

increased vertical stereotypic behavior ( J:175800 )

growth/size/body

decreased body weight ( J:175800 )

cellular

increased neuron apoptosis ( J:175800 )

• in the striatum at E14.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:175800