Phenotypes Associated with This Genotype

Genotype
MGI:5292662

• Allelic Composition: Tg(tetO-TAg)2-5Hiwa/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:156984 )

• die at 18-28 weeks of age

neoplasm

increased adrenal gland tumor incidence ( J:175962 )

• beginning at 13 weeks of age, mutants develop carcinoma of the adrenal gland

increased neuroblastoma incidence ( J:156984 , J:175962 )

• all mutants have bilateral large adrenal tumors (J:156984)

• pathological analysis indicates that tumors are consistent with adrenal neuroblastoma (J:156984)

• tumors secrete dopamine and some secrete noradrenalin or adrenaline (J:156984)

• mice exhibit tumors resembling adrenal neuroblastoma not pheochromocytoma (J:175962)

endocrine/exocrine glands

adrenal medulla hyperplasia ( J:175962 )

• mild hyperplasia in the adrenal medulla is seen by 5 and 9 weeks of age

increased adrenal gland tumor incidence ( J:175962 )

• beginning at 13 weeks of age, mutants develop carcinoma of the adrenal gland

cardiovascular system

cardiovascular system phenotype ( J:175962 )

N • mutants exhibit normal blood pressure

nervous system

increased neuroblastoma incidence ( J:156984 , J:175962 )

• all mutants have bilateral large adrenal tumors (J:156984)

• pathological analysis indicates that tumors are consistent with adrenal neuroblastoma (J:156984)

• tumors secrete dopamine and some secrete noradrenalin or adrenaline (J:156984)

• mice exhibit tumors resembling adrenal neuroblastoma not pheochromocytoma (J:175962)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:156984 , J:175962