Analysis Tools
behavior/neurological
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• context freezing response is significantly reduced
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• cued fear conditioning response is reduced after a 48 h retention delay
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• resident males show a shorter latency to attack and attack for a longer duration with a higher frequency
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• spend more time in the center of an open field and spend more time in the open arms of a plus maze compared to controls
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• fail to show a preference for a novel mouse
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• decrease in interaction with a novel object compared to controls
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• pups are more scattered in the home cage
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• show a significantly shorter duration of crouching to keep the pups warm and to nurse them
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• show little nest building activity and build shallower nest compared to controls
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• males display persistent interest when presented with the same female indicating a failure to develop social memory
• fail to show a preference for a novel mouse
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• in an open field test for social versus inanimate preference, mice show no significant difference in time spent interacting with the social or inanimate targets unlike controls
• in a sociability test for social versus empty preference, mice show a significant decrease in interaction with the social target compared to controls
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nervous system
astrocytosis
(
J:176051
)
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• in the cortices at 13 weeks of age
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taste/olfaction
| N |
• no defect in olfaction is detected
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:176051 | ||
