Phenotypes Associated with This Genotype

Genotype
MGI:5294332

• Allelic Composition: Col11a1^cho/Col11a1⁺
• Genetic Background: involves: C57BL/6Fr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal knee joint morphology ( J:106282 )

• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice

• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice

skeleton

osteoarthritis ( J:106282 )

• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice

• cartilage degeneration increases between 9 and 15 months of age

abnormal knee joint morphology ( J:106282 )

• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice

• at 6 months, mice exhibit a loss of proteoglycan at the knee joint compared with wild-type mice

abnormal chondrocyte morphology ( J:106282 )

• at 3 months, a large number of chondrocyte clusters are present in the superficial layer of articular cartilage in the knee joint unlike in wild-type mice

abnormal joint mobility ( J:106282 )

• tensile stiffness in articular cartilage of the knee joint is moderately reduced compared to in wild-type mice

immune system

osteoarthritis ( J:106282 )

• by 15 months, mice exhibit loss of articular cartilage, misshaped meniscus, and inflammation in the synovial tissues in the knee and tenporomandibular joints unlike in wild-type mice

• cartilage degeneration increases between 9 and 15 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:106282