Phenotypes Associated with This Genotype

Genotype
MGI:5294346

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/0; Tg(TPO-cre)1Shk/0
• Genetic Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:177181 )

• pioglitazone-fed mice exhibit lipid accumulation in thyroid cells

enlarged thyroid gland ( J:177181 )

• 100-fold increase in size

• larger than in Pten^tm1Hwu/Pten^tm1Hwu Tg(TPO-cre)1Shk mice

• irregularly shaped, mutlinodular, more cellular than colloid

• however, pioglitazone (a PPARG inhibitor) decreases thyroid size

increased thyroid carcinoma incidence ( J:177181 )

• with metastasis to the lungs and soft tissues

• however, pioglitazone (a PPARG inhibitor) induces a lipogenic antitumor response

abnormal thymus physiology ( J:177181 )

• pioglitazone-fed mice exhibit decreased thyroid size due to increased apoptosis

homeostasis/metabolism

increased circulating thyroxine level ( J:177181 )

• 6-fold

• however, pioglitazone normalizes thyroid function

increased circulating triiodothyronine level ( J:177181 )

• 3.5-fold

• however, pioglitazone normalizes thyroid function

neoplasm

increased thyroid carcinoma incidence ( J:177181 )

• with metastasis to the lungs and soft tissues

• however, pioglitazone (a PPARG inhibitor) induces a lipogenic antitumor response

immune system

abnormal thymus physiology ( J:177181 )

• pioglitazone-fed mice exhibit decreased thyroid size due to increased apoptosis

hematopoietic system

abnormal thymus physiology ( J:177181 )

• pioglitazone-fed mice exhibit decreased thyroid size due to increased apoptosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland carcinoma		DOID:3963		J:177181