Phenotypes Associated with This Genotype

Genotype
MGI:5294359

• Allelic Composition: Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}/Trib2⁺; Tg(Thy1-APP*)2.2Ingm/0
• Genetic Background: involves: C57BL/6 * DBA/1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

hippocampus pyramidal cell degeneration ( J:176575 )

• neurodegeneration in the CA1 pyramidal cell layer

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

astrocytosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

behavior/neurological

impaired righting response ( J:176575 )

• delayed

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

limb grasping ( J:176575 )

• display cramping or tremors when lifted by the tail

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

growth/size/body

decreased body weight ( J:176575 )

slow postnatal weight gain ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

hematopoietic system

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

immune system

microgliosis ( J:176575 )

• onset is later than in mice homozygous for Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:176575