Phenotypes Associated with This Genotype

Genotype
MGI:5296910

• Allelic Composition: Cacna1c^tm2Itl/Cacna1c⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:176442 )

behavior/neurological

behavior/neurological phenotype ( J:176442 )

N • mice exhibit normal behavior in a light/dark box test and elevated zero maze

N • mice exhibit normal spatial reference memory acquisition and retrieval in a Morris water maze

enhanced contextual conditioning behavior ( J:176442 )

• mice exhibit increased persistence of contextual fear memory compared with wild-type mice

enhanced cued conditioning behavior ( J:176442 )

• mice exhibit increased persistence of tone-cued fear memory compared with wild-type mice

decreased exploration in new environment ( J:176442 )

• mice spent a smaller fraction of time moving, fewer ambulatory movements, and smaller distance traveled in a novel environment compared with wild-type mice

• mice exhibit decreased approach behavior in a novel environment compared with wild-type mice

• however, mice do not exhibit thigmotaxis

increased stereotypic behavior ( J:176442 )

• mice exhibit repetitive and preservative behaviors in marble burying, Morris water maze (during reversal training), and water Y-maze compared with wild-type mice

abnormal social investigation ( J:176442 )

• in a social home-cage assay, mice exhibit reduced social preference compared with wild-type mice

decreased vocalization ( J:176442 )

• at P6, P8, and P10, mice exhibit shorter duration of ultrasonic vocalization compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Timothy syndrome		DOID:0060173	OMIM:601005	J:176442