Phenotypes Associated with This Genotype

Genotype
MGI:5297135

• Allelic Composition: Brca1^tm2Cxd/Brca1^tm2Cxd; Tg(MMTV-cre)4Mam/0; Tg(MMTV-rtTA)1Lach/0; Tg(tetO-Esr1)#Paf/0; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:132088 )

♀ • mutants develop hyperplastic alveolar nodules

increased mammary gland tumor incidence ( J:132088 )

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

neoplasm

increased mammary gland tumor incidence ( J:132088 )

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

preneoplasia ( J:132088 )

• mutants develop mammary gland preneoplasia

• some preneoplasia are Esr1-negative while others are Esr1-positive

integument

mammary gland alveolar hyperplasia ( J:132088 )

♀ • mutants develop hyperplastic alveolar nodules

increased mammary gland tumor incidence ( J:132088 )

• 100% of mutants develop invasive mammary cancer

• some cancers are Esr1-negative while others are Esr1-positive

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary breast ovarian cancer syndrome		DOID:5683		J:132088