Phenotypes Associated with This Genotype

Genotype
MGI:5297860

• Allelic Composition: A^y/a; Apoe^tm1Unc/Apoe^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:177084 )

• mutants develop larger atherosclerotic plaques than a/a Apoe^tm1Unc/Apoe^tm1Unc mice

• plaques contain a higher proportion of macrophage infiltration

growth/size/body

obese ( J:177084 )

• mutants exhibit increased weight gain, despite similar food intake as controls

hematopoietic system

increased monocyte cell number ( J:177084 )

• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

homeostasis/metabolism

hyperglycemia ( J:177084 )

increased circulating insulin level ( J:177084 )

increased circulating leptin level ( J:177084 )

increased circulating cholesterol level ( J:177084 )

increased circulating triglyceride level ( J:177084 )

insulin resistance ( J:177084 )

decreased circulating adiponectin level ( J:177084 )

immune system

increased monocyte cell number ( J:177084 )

• increase in the proportion of inflammatory monocytes in the blood, liver, muscle, and kidney, but not epididymal fat pads

abnormal inflammatory response ( J:177084 )

• increase in systemic inflammation

renal/urinary system

abnormal kidney morphology ( J:177084 )

• mutants develop features of diabetic nephropathy

abnormal glomerular mesangium morphology ( J:177084 )

• mutants exhibit mesangial expansion as indicated by glycogen deposition in the glomeruli

glomerulosclerosis ( J:177084 )

• 20-30% of mutants exhibit nodular sclerosis in the kidney

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome		DOID:0060611	OMIM:PS605552	J:177084