muscle
• under basal conditions, mice exhibit mild alterations in skeletal muscle morphology compared with wild-type mice
• following repeated forced swimming tests, muscles accumulate tubular aggregates unlike wild-type cells
|
• following repeated forced swimming tests
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• following repeated forced swimming tests
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• following repeated forced swimming tests
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• following repeated forced swimming tests
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• under basal conditions at 3 and 10 months of age
• following repeated forced swimming tests
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• following repeated forced swimming tests, mice exhibit a switch towards slower and smaller fibers in paravertebral muscles compared with wild-type mice
• however, fiber type ratios are normal under basal conditions and in the quadriceps of mice subjected to repeated forced swimming tests
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• in the paravertebral muscles under basal conditions
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• in one mouse subjected to repeated forced swimming tests
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• following repeated forced swimming tests, mice exhibit a switch towards slower and smaller fibers in paravertebral muscles compared with wild-type mice
• however, fiber type ratios are normal under basal conditions and in the quadriceps of mice subjected to repeated forced swimming tests
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• in the tibialis anterior, quadriceps, gastrocnemius, and extensor digitorum longus muscles following 1.5 months of repeated forced swimming tests, to a lesser extent in female mice
• however, diaphragm and heart weight is normal following repeated forced swimming tests
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• in the tibialis anterior under basal conditions
• in one mouse subjected to repeated forced swimming tests
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• mild decrease in the absolute maximal titanic force under basal conditions
• after 4 to 6 weeks repeated forced swim activity, mice exhibit progressive rigidity of the trunk and limbs and a reduction in motility unlike wild-type mice
• however, mice subjected to daily forced swimming tests exhibit normal specific maximal force of the tibialis anterior and diaphragm as well as response to fatigue
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growth/size/body
• following 1.5 and 3 months of repeated forced swimming tests
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skeleton
• severe after 4 to 6 weeks daily swim activity, worsening with repeated forced swim training and age
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limbs/digits/tail
• following repeated forced swimming tests
|
• following repeated forced swimming tests
|
• following repeated forced swimming tests
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• following repeated forced swimming tests
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• under basal conditions at 3 and 10 months of age
• following repeated forced swimming tests
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
rigid spine muscular dystrophy 1 | DOID:0110633 |
OMIM:602771 |
J:176499 |