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Phenotypes Associated with This Genotype
Genotype
MGI:5298009
Allelic
Composition
Selenontm1.2Mred/Selenontm1.2Mred
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selenontm1.2Mred mutation (2 available); any Selenon mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• under basal conditions, mice exhibit mild alterations in skeletal muscle morphology compared with wild-type mice
• following repeated forced swimming tests, muscles accumulate tubular aggregates unlike wild-type cells
• following repeated forced swimming tests
• following repeated forced swimming tests
• following repeated forced swimming tests
• following repeated forced swimming tests
• under basal conditions at 3 and 10 months of age
• following repeated forced swimming tests
• following repeated forced swimming tests, mice exhibit a switch towards slower and smaller fibers in paravertebral muscles compared with wild-type mice
• however, fiber type ratios are normal under basal conditions and in the quadriceps of mice subjected to repeated forced swimming tests
• in the paravertebral muscles under basal conditions
• in one mouse subjected to repeated forced swimming tests
• following repeated forced swimming tests, mice exhibit a switch towards slower and smaller fibers in paravertebral muscles compared with wild-type mice
• however, fiber type ratios are normal under basal conditions and in the quadriceps of mice subjected to repeated forced swimming tests
• in the tibialis anterior, quadriceps, gastrocnemius, and extensor digitorum longus muscles following 1.5 months of repeated forced swimming tests, to a lesser extent in female mice
• however, diaphragm and heart weight is normal following repeated forced swimming tests
• in the tibialis anterior under basal conditions
• in one mouse subjected to repeated forced swimming tests
• mild decrease in the absolute maximal titanic force under basal conditions
• after 4 to 6 weeks repeated forced swim activity, mice exhibit progressive rigidity of the trunk and limbs and a reduction in motility unlike wild-type mice
• however, mice subjected to daily forced swimming tests exhibit normal specific maximal force of the tibialis anterior and diaphragm as well as response to fatigue

growth/size/body
• following 1.5 and 3 months of repeated forced swimming tests

skeleton
• severe after 4 to 6 weeks daily swim activity, worsening with repeated forced swim training and age

limbs/digits/tail
• following repeated forced swimming tests
• following repeated forced swimming tests
• following repeated forced swimming tests
• following repeated forced swimming tests
• under basal conditions at 3 and 10 months of age
• following repeated forced swimming tests

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rigid spine muscular dystrophy 1 DOID:0110633 OMIM:602771
J:176499


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory