Phenotypes Associated with This Genotype

Genotype
MGI:5298084

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin squamous cell carcinoma incidence ( J:172048 )

• lesions are squamous cell carcinomas (SCCs)characterized by fibroblast-like shaped cells and disruption of basal lamina

• numerous microscopic and small invasive SCCs are observed in the dermis of the back skin in addition to the macroscopic lesions

integument

skin lesions ( J:172048 )

• within 2 months of tamoxifen treatment, animals develop rapidly growing ulcerative skin lesions in the back skin

increased skin squamous cell carcinoma incidence ( J:172048 )

• lesions are squamous cell carcinomas (SCCs)characterized by fibroblast-like shaped cells and disruption of basal lamina

• numerous microscopic and small invasive SCCs are observed in the dermis of the back skin in addition to the macroscopic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
squamous cell carcinoma		DOID:1749		J:172048