Phenotypes Associated with This Genotype

Genotype
MGI:5300204

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Scrib^tm1.1Phum/Scrib^tm1.1Phum; Tg(Pbsn-cre)20Fwan/0
• Genetic Background: involves: 129S4/SvJae * FVB/NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:178461 )

• 3 of 10 mice exhibit signs of illness and were sacrificed prior to 400 days

reproductive system

prostate gland hyperplasia ( J:178461 )

♂

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 20% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 33% of mice

abnormal prostate gland physiology ( J:178461 )

♂ • increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 33% of mice

increased carcinoma incidence ( J:178461 )

• 3 of 15 mice develop poorly differentiated invasive carcinoma

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

prostate gland hyperplasia ( J:178461 )

♂

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 20% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 33% of mice

abnormal prostate gland physiology ( J:178461 )

♂ • increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:178461