Phenotypes Associated with This Genotype

Genotype
MGI:5300205

cn4

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Scrib^tm1.1Phum/Scrib⁺; Tg(Pbsn-cre)20Fwan/0
• Genetic Background: involves: 129S4/SvJae * FVB/NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

♂ • increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:178461 )

♂ • well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

♂ • high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

♂ • increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice