Phenotypes Associated with This Genotype

Genotype
MGI:5300565

• Allelic Composition: Col1a2^tm1.1Mcbr/Col1a2⁺
• Genetic Background: (C3H/HeJ x B6.129-Col1a2^tm1.1Mcbr)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:178743 )

skeleton

decreased bone mineral content ( J:178743 )

• decreased bone mineral content

• lower cortical volumetric tissue mineral content

increased bone mineral density ( J:178743 )

• Background Sensitivity: bone mineral density is lowest on the mixed C3H/HeJ and C57BL/6 background compared to F1 crosses to A/J, BALB/cByJ, or FVB/NJ

increased volumetric bone mineral density ( J:178743 )

• cortical volumetric tissue mineral density (vTMD) is elevated in the femur

decreased bone volume ( J:178743 )

decreased compact bone area ( J:178743 )

decreased compact bone thickness ( J:178743 )

decreased bone trabecula number ( J:178743 )

• fewer and more widely spaced trabeculae

decreased bone strength ( J:178743 )

• femurs are weaker and more brittle

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteogenesis imperfecta		DOID:12347	OMIM:PS166200	J:178743