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Phenotypes Associated with This Genotype
Genotype
MGI:5301407
Allelic
Composition		 Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background		 FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (76 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:178230 )
• increase in microgliosis
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

hematopoietic system
microgliosis ( J:178230 )
• increase in microgliosis

immune system
microgliosis ( J:178230 )
• increase in microgliosis

homeostasis/metabolism
amyloid beta deposits ( J:178230 )
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:178230

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory