Phenotypes Associated with This Genotype

Genotype
MGI:5301410

• Allelic Composition: Abcc1^tm1Bor/Abcc1^tm1Bor; Tg(Thy1-APPDutch)#Jckr/0
• Genetic Background: FVB.Cg-Abcc1^tm1Bor Tg(Thy1-AppDutch)#Jckr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:178230 )

• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy

• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

homeostasis/metabolism

amyloid beta deposits ( J:178230 )

• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy

• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

abnormal homeostasis ( J:178230 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:178230