Phenotypes Associated with This Genotype

Genotype
MGI:5301577

• Allelic Composition: Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik; Tg(Ins2-cre)25Mgn/0
• Genetic Background: B6.Cg-Cdkal1^tm1.1Tomik Tg(Ins2-cre)25Mgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Endoplasmic reticulum distention in Cdkal1^tm1.2Tomik/Cdkal1^tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:178248 )

• the number of small islets is lower and the number of large islets is greater than in control mice

• however, the total number of islets is normal

abnormal pancreatic beta cell physiology ( J:178248 )

• beta cells exhibit endoplasmic reticulum stress unlike control cells

• beta cells exhibit decreased glucose-stimulated ATP synthesis compared with control cells

abnormal insulin secretion ( J:178248 )

• the first-phase of insulin secretion is impaired

• however, the second-phase is normal

decreased insulin secretion ( J:178248 )

• in beta cells 15 minutes after glucose challenge

• following prostprandial stimulation

• in mice fed a high-fat diet

homeostasis/metabolism

abnormal insulin secretion ( J:178248 )

• the first-phase of insulin secretion is impaired

• however, the second-phase is normal

decreased insulin secretion ( J:178248 )

• in beta cells 15 minutes after glucose challenge

• following prostprandial stimulation

• in mice fed a high-fat diet

increased circulating glucose level ( J:178248 )

• in fasting and nonfasting mice fed a high-fat diet

impaired glucose tolerance ( J:178248 )

• at 5 to 10 weeks of age

• in mice fed a high-fat diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:178248