Phenotypes for Lzts2 MGI:5302224 MGI Mouse

renal/urinary system

abnormal renal/urinary system morphology ( J:178154 )

• between 4 and 12 months of age most mice develop some abnormalities in the urinary tract

abnormal kidney morphology ( J:178154 )

kidney cyst ( J:178154 )

• multiple macroscopic and microscopic cysts are seen in some (4 of 21) mice

• cysts originate mainly from the collecting ducts

abnormal renal glomerulus morphology ( J:178154 )

• lack of glomerular structures in some mice

abnormal kidney epithelium morphology ( J:178154 )

• expression analysis indicates changes in the adhesion properties of the tubular epithelial cells

double kidney pelvis ( J:178154 )

• double renal pelvis in some neonates

hydronephrosis ( J:178154 )

• seen at E17.5

• some mice display left, right, or bilateral kidney hydronephrosis at 4 to 12 months of age

dilated renal tubule ( J:178154 )

• in some mice

duplex kidney ( J:178154 )

• duplicated left kidney in some mice

abnormal ureter morphology ( J:178154 )

dilated ureter ( J:178154 )

• mild dilation in some mice

double ureter ( J:178154 )

• double ureters are seen at E17.5

• duplicated right ureters in some mice between 4 and 12 months

hydroureter ( J:178154 )

• at E17.5

short ureter ( J:178154 )

• in some mice

abnormal urinary system development ( J:178154 )

• abnormal urinary tract development is seen in most mice at 4 to 12 months of age

ectopic ureteric bud ( J:178154 )

• at E11.5 ectopic ureteric buds are present which are more anterior to the normal location

embryo

abnormal Wolffian duct morphology ( J:178154 )

• at E10.5 the entire end of the Wolffian duct is much broader and bifurcated

reproductive system

abnormal seminal vesicle morphology ( J:178154 )

• malformed left seminal vesicle in some mice

dilated seminal vesicle ( J:178154 )

• left seminal vesicle ectasia in some mice

abnormal uterine horn morphology ( J:178154 )

• left uterine horn pyometra in some mice

endocrine/exocrine glands