Phenotypes Associated with This Genotype

Genotype
MGI:5303093

• Allelic Composition: Ednrb^tm1Ywa/Ednrb⁺; Tg(Mt1-RET)304Ina/0
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:155735 )

• life span after tumor development is shorter than in single Tg(Mt1-RET)304Ina hemizygotes

neoplasm

increased metastatic potential ( J:155735 )

• lung metastasis after tumor development is significantly higher than in Tg(Mt1-RET)304Ina hemizygotes

increased melanoma incidence ( J:155735 )

• melanomagenesis proceeds without a pre-existing benign lesion, indicating de novo melanoma development

• location and shape of tumors is similar to those in single Tg(Mt1-RET)304Ina hemizygotes

• 68.8% of tumors less than 500 mm³ in size are malignant and the rest (31.2%) are premalignant

• 80.8% tumors from mutants are malignant and the rest are premalignant

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:155735