Phenotypes Associated with This Genotype

Genotype
MGI:5304474

• Allelic Composition: Tg(RP11-209M4)AGglo/Tg(RP11-209M4)AGglo
• Genetic Background: FVB-Tg(RP11-209M4)4Gglo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal phalanx morphology ( J:179873 )

• mice exhibit a wide range of fused and missing digits

fused phalanges ( J:179873 )

decreased bone volume ( J:179873 )

• to a greater extent than in mice hemizygous for transgene insertion

abnormal bone ossification ( J:179873 )

• mice exhibit impaired bone formation rate compared with non-transgenic mice and to a greater extent than in mice hemizygous for transgene insertion

limbs/digits/tail

abnormal phalanx morphology ( J:179873 )

• mice exhibit a wide range of fused and missing digits

fused phalanges ( J:179873 )

abnormal digit development ( J:179873 )

• mice exhibit a wide range of fused and missing digits

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
SOST-related sclerosing bone dysplasia		DOID:0080036	OMIM:239100	J:99965