Phenotypes Associated with This Genotype

Genotype
MGI:5304757

• Allelic Composition: Col1a1^{tm1(tetO-RNAi:Rps19)Karl}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:179085 )

N • unlike homozygous mice, heterozygotes survive at least 3 months following doxycycline treatment

hematopoietic system

abnormal bone marrow cell morphology/development ( J:179085 )

• decrease in the frequency of bipotential megakaryocytic-erythroid cells and preGM/GMP progenitor cells at 7 weeks after doxycycline treatment

decreased bone marrow cell number ( J:179085 )

• by 10 days after doxycycline treatment

• absolute numbers of all hematopoietic stem and progenitor cells are reduced at 7 weeks after doxycycline treatment

decreased megakaryocyte cell number ( J:179085 )

• seven weeks after doxycycline treatment

abnormal proerythroblast morphology ( J:179085 )

• decrease in the frequency or proerythroblasts in the bone marrow by 10 days after doxycycline treatment

macrocytosis ( J:179085 )

• seven weeks after doxycycline treatment

thrombocytosis ( J:179085 )

• two weeks after doxycycline treatment

decreased hematopoietic cell number ( J:179085 )

decreased erythrocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

decreased lymphocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

reticulocytopenia ( J:179085 )

• two weeks after doxycycline treatment

abnormal bone marrow cell physiology ( J:179085 )

• preMegE and preCFU-E/CFU-E progenitors show impaired proliferation and increased apoptosis following doxycycline treatment

immune system

decreased lymphocyte cell number ( J:179085 )

• two and seven weeks after doxycycline treatment

growth/size/body

postnatal growth retardation ( J:179085 )

• following doxycycline treatment

• less pronounced than in homozygous mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Diamond-Blackfan anemia		DOID:1339	OMIM:PS105650	J:179085