Phenotypes Associated with This Genotype

Genotype
MGI:5305090

hm1

• Allelic Composition: Ror2^Y324C/Ror2^Y324C
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ror2^Y324C/Ror2^Y324C and Ror2^tm1Ymi/Ror2^tm1Ymi mice exhibit short tails at E10.75

mortality/aging

perinatal lethality ( J:179805 )

reproductive system

decreased primordial germ cell number ( J:179805 )

• total numbers and the number in the gonads are decreased at E11.5 and E12.5, but not at E10.5

abnormal reproductive system physiology ( J:179805 )

• cultured primordial germ cells show impaired elongation and alignment along an SCF (secreted Kit ligand) gradient

increased primordial germ cell apoptosis ( J:179805 )

• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5

abnormal primordial germ cell migration ( J:179805 )

• ectopic PGCs are seen in the allantois, throughout the tail mesoderm, and caudal hindgut at E9.0

• fail to migrate rostrally at E10.5, remaining in the mesentery surrounding the caudal hindgut as well as on the surface of the tail and in the allantois

• at E11.5 the distribution of PGCs is skewed toward the caudal end of the gonad and an increased number of extragonadal PGCs are present in midline tissues

• ectopic PGCs make up 30% of the total PGCs at E11.5 compared to less than 5% in wild-type controls

• cell elongation of migratory PGCs is impaired at E9.75-E10.75

digestive/alimentary system

abnormal hindgut morphology ( J:179805 )

• wider and shorter caudal hindgut at E9.5

limbs/digits/tail

abnormal tail development ( J:179805 )

• defects in tail elongation

embryo

impaired somite development ( J:179805 )

• defects in somite segmentation

cellular

decreased primordial germ cell number ( J:179805 )

• total numbers and the number in the gonads are decreased at E11.5 and E12.5, but not at E10.5

increased primordial germ cell apoptosis ( J:179805 )

• increase in apoptosis of extragonadal primordial germ cells at E10.5 and E11.5

abnormal primordial germ cell migration ( J:179805 )

• ectopic PGCs are seen in the allantois, throughout the tail mesoderm, and caudal hindgut at E9.0

• fail to migrate rostrally at E10.5, remaining in the mesentery surrounding the caudal hindgut as well as on the surface of the tail and in the allantois

• at E11.5 the distribution of PGCs is skewed toward the caudal end of the gonad and an increased number of extragonadal PGCs are present in midline tissues

• ectopic PGCs make up 30% of the total PGCs at E11.5 compared to less than 5% in wild-type controls

• cell elongation of migratory PGCs is impaired at E9.75-E10.75