Phenotypes Associated with This Genotype

Genotype
MGI:5305095

• Allelic Composition: Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:179879 )

neoplasm

increased chronic lymphocytic leukemia incidence ( J:179879 )

increased lymphoma incidence ( J:179879 )

• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

increased small lymphocytic lymphoma incidence ( J:179879 )

immune system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 42% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

hematopoietic system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 42% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:179879