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Phenotypes Associated with This Genotype
Genotype
MGI:5305096
Allelic
Composition
Del(14Trim13-Rnaseh2b)6Rdf/+
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available); any Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 70% of mice die by 20 months

neoplasm
• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

immune system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 25% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo

hematopoietic system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 25% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory