About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5305097
Allelic
Composition
Is(14)1Rdf/Is(14)1Rdf
Is(14)5Rdf/Is(14)5Rdf
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)5Rdf mutation (1 available); any Is(14)5Rdf mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

immune system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 67% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo

hematopoietic system
• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220lo) with characteristics of chronic lymphocytic leukemia
• 67% of mice develop clonal lymphoproliferations
• IgM+CD5+B220lo


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory