Phenotypes Associated with This Genotype

Genotype
MGI:5305254

• Allelic Composition: Sirt1^tm1.2Cxd/Sirt1^tm1.2Cxd; Tg(Alb1-cre)1Dlr/?
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased liver triglyceride level ( J:179193 )

• become significantly elevated

hepatic steatosis ( J:179193 )

• liver is histologically normal at 2 months but with some lipid droplet accumulation

• livers at 6 months were fat in about 56% of mice

• livers at 12 months were fat in about 78% of mice but only 17% of controls

homeostasis/metabolism

increased circulating free fatty acids level ( J:179193 )

• serum levels become modestly elevated

increased circulating triglyceride level ( J:179193 )

• becomes moderately elevated

increased liver triglyceride level ( J:179193 )

• become significantly elevated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
steatotic liver disease		DOID:9452	OMIM:228100	J:179193