Phenotypes Associated with This Genotype

Genotype
MGI:5305581

• Allelic Composition: Hsf4^ldis1/Hsf4^ldis1
• Genetic Background: involves: C57BL/6 * CAST/EiJ * RIIIS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:179658 )

• persistence of nuclei in lens fiber cells as early as P0.5

• by P10-12, lenses develop severely vauolated cataracts often accompanied by rupture of the lens capsule and release of the lenticular material in the vitreous cavity, such that cataracts are visible upon eyelid opening between P12-14

• vacuoles are seen in the cortex and nucleus of the lens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 5 multiple types		DOID:0110255	OMIM:116800	J:179658