Phenotypes Associated with This Genotype

Genotype
MGI:5305730

• Allelic Composition: Fgf23^tm1.1Kew/Fgf23^tm1.1Kew
• Genetic Background: B6.129-Fgf23^tm1.1Kew

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Fgf23^tm1.1Kew/Fgf23^tm1.1Kew mice fed a low-iron diet exhibit osteomalacia

skeleton

abnormal compact bone morphology ( J:180061 )

• mice fed a low-iron diet exhibit osteocytic lesions in the cortical bone proximal to the metaphysis unlike wild-type mice

abnormal osteoid morphology ( J:180061 )

• osteoid surface to bone surface is increased 9-fold in mice fed a low-iron diet compared with wild-type mice

increased osteoid thickness ( J:180061 )

• in mice fed a low-iron diet

osteomalacia ( J:180061 )

• in the cancellous bone of mice fed a low-iron diet

homeostasis/metabolism

decreased circulating phosphate level ( J:180061 )

• on a low-iron diet at 8 and 12 weeks

increased circulating alkaline phosphatase level ( J:180061 )

• on a low-iron diet at 8 and 12 weeks

abnormal vitamin D level ( J:180061 )

• erum vitamin D levels are decreased in mice fed a low-iron diet compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant hypophosphatemic rickets		DOID:0050948	OMIM:193100	J:180061