About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5306255
Allelic
Composition		 Bdnftm3Jae/Bdnftm3Jae
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm3Jae mutation (2 available); any Bdnf mutation (42 available)
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:106973 )
• life span is shorter than in Mecp2 single homozygous mice

behavior/neurological
lethargy ( J:106973 )
• dramatic reduction in wheel running activity at 4 weeks of age

nervous system
abnormal action potential ( J:106973 )
• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
 J:106973

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory