Phenotypes for Col1a1 Mecp2 Tg(Camk2a-cre)93Kln MGI:5306257 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Col1a1^{tm8(CAG-BDNF)Jae}/Col1a1⁺ Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm8(CAG-BDNF)Jae} mutation (0 available); any Col1a1 mutation (163 available)
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:106973 )

• life span is significantly longer than in Mecp2 single hemizygous mice

behavior/neurological

behavior/neurological phenotype ( J:106973 )

N	• overexpression of BDNF improves locomotor function compared to Mecp2 single hemizygous mice at 6 weeks of age

nervous system

decreased brain weight ( J:106973 )

• decreased compared to wild-type littermates but modestly increased compared to Mecp2 single hemizygous mice

abnormal action potential ( J:106973 )

• firing rate is increased compared to Mecp2 single hemizygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24