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Phenotypes Associated with This Genotype
Genotype
MGI:5306345
cn6
Allelic
Composition		 Col1a1tm8(CAG-BDNF)Jae/Col1a1tm8(CAG-BDNF)Jae
Tg(Sim1-cre)1Lowl/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm8(CAG-BDNF)Jae mutation (0 available); any Col1a1 mutation (166 available)
Tg(Sim1-cre)1Lowl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hypothalamus physiology ( J:179918 )
• elevated immunoreactivity for corticotropin-releasing hormone in the paraventricular nucleus

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:179918 )
N
• despite increase in corticotropin-releasing hormone levels in the paraventricular nucleus, circulating adrenocorticotropin and corticosterone are largely unaffected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory