Phenotypes Associated with This Genotype

Genotype
MGI:5306390

• Allelic Composition: Eif2b5^tm1Itl/Eif2b5^tm1Itl
• Genetic Background: involves: 129S/SvEv * C57BL * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain white matter morphology ( J:179801 )

• abnormal development of brain white matter

abnormal brain internal capsule morphology ( J:179801 )

• as detected by MRI

• however, older mice exhibit normal isotropy values in an MRI

abnormal astrocyte morphology ( J:179801 )

• decreased astrocyte numbers at 3 weeks but not 4 months

increased oligodendrocyte number ( J:179801 )

• at 3 weeks but not 4 months

abnormal axon morphology ( J:179801 )

• young mice exhibit a higher portion of small-caliber axons compared with wild-type mice

demyelination ( J:179801 )

• late-onset myelin degeneration

• impaired recovery from cuprizone-induced demyelination

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:179801 )

• impaired recovery from cuprizone-induced demyelination

adipose tissue

decreased percent body fat/body weight ( J:179801 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
leukoencephalopathy with vanishing white matter		DOID:0060868	OMIM:PS603896	J:179801