Phenotypes Associated with This Genotype

Genotype
MGI:5306592

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Tg(Sftpc-cre)1Blh/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased lung apoptosis ( J:179883 )

• mutants exhibit an increase in apoptotic cells in the lungs

respiratory system

increased lung apoptosis ( J:179883 )

• mutants exhibit an increase in apoptotic cells in the lungs

lung inflammation ( J:179883 )

• mutants exhibit infiltration of atypical foamy alveolar macrophages

• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation

abnormal pulmonary alveolar system morphology ( J:179883 )

• 3 month old mutants exhibit enlarged air spaces and infiltration of atypical foamy alveolar macrophages

• progressive destruction of alveolar tissue

emphysema ( J:179883 )

• mutants develop progressive emphysema

abnormal pulmonary alveolar parenchyma morphology ( J:179883 )

• localized destruction leading to large cavities in the parenchyma

immune system

abnormal cytokine level ( J:179883 )

• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL

abnormal tumor necrosis factor level ( J:179883 )

• an elevated level of TNF-alpha is seen in the BAL fluid

lung inflammation ( J:179883 )

• mutants exhibit infiltration of atypical foamy alveolar macrophages

• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation

homeostasis/metabolism

abnormal cytokine level ( J:179883 )

• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL

abnormal tumor necrosis factor level ( J:179883 )

• an elevated level of TNF-alpha is seen in the BAL fluid

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary emphysema		DOID:9675	OMIM:130700	J:179883