Phenotypes Associated with This Genotype

Genotype
MGI:5307256

• Allelic Composition: Brca1^tm1Brn/Brca1^tm1.1Jjon; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:178595 )

• compared to KB1P littermate controls homozygous

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

decreased skin tumor incidence ( J:178595 )

• markedly lower incidence compared to KB1P littermate controls

abnormal tumor pathology ( J:178595 )

• in transplanted tumors response to olaparib treatment is impaired compared to KB1P littermate controls but better than in KP mice

• transplanted tumors develop resistance to cisplatin and survival of transplanted mice is worse than that of mice transplanted with tumors from KB1P mice

abnormal tumor morphology ( J:178595 )

• increased genomic instability in tumors compared to mice homozygous for Trp53^tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)

decreased tumor latency ( J:178595 )

• median latency is 197 days compared to 236 days in littermate controls homozygous for Brca1^tm1Brn Trp53^tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1P)

• however, no difference in the latency of mammary tumor development

integument

decreased mammary gland tumor incidence ( J:178595 )

• compared to KB1P littermate controls homozygous

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

decreased skin tumor incidence ( J:178595 )

• markedly lower incidence compared to KB1P littermate controls

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:178595 )

• compared to KB1P littermate controls homozygous

• most mammary tumors are poorly differentiated solid carcinomas

• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:178595