neoplasm
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
|
• compared to KB1C61GP littermate controls
|
• in transplanted tumors response to olaparib treatment is improved compared to KB1C61GP littermate controls and KP mice
• transplanted tumors never develop resistance to cisplatin unlike tumors from KP mice
|
• increased genomic instability in tumors compared to mice homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KP mice)
|
• median latency is 236 days compared to 197 days in littermate controls heterozygous for Brca1tm1Brn and Brca1tm1.1Jjon, homozygous for Trp53tm1Brn and carrying Tg(KRT14-cre)8Brn (KB1C61GP)
|
integument
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
|
• compared to KB1C61GP littermate controls
|
endocrine/exocrine glands
• compared to KB1C61GP littermate controls
• most mammary tumors are poorly differentiated solid carcinomas
• a small percentage of tumors are classified as carcinosarcomas or lumen forming carcinomas
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
breast cancer | DOID:1612 |
OMIM:114480 |
J:178595 |