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Phenotypes Associated with This Genotype
Genotype
MGI:5307915
cn2
Allelic
Composition		 Cacna1atm1Kano/Cacna1atm1Kano
Grin2ctm2(icre)Mwa/Grin2c+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1atm1Kano mutation (0 available); any Cacna1a mutation (118 available)
Grin2ctm2(icre)Mwa mutation (0 available); any Grin2c mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:180582 )
N
• size and histology of cerebellum is normal; thickness and cell density of granular layer is normal
• proximal dendrites and soma of Purkinje cells are normal; parallel fiber terminals are normal in size and do not display multiple contacts, and climbing fiber terminals do not show regressed innervation territory as observed in Purkinje cell specific-Cacna1a mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory