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Phenotypes Associated with This Genotype
Genotype
MGI:5308014
Allelic
Composition
Il6tm1Kopf/Il6tm1Kopf
Tg(ED-L2-IL1RN/IL1B)#Tcw/?
Genetic
Background
B6.Cg-Il6tm1Kopf Tg(ED-L2-IL1RN/IL1B)#Tcw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Tg(ED-L2-IL1RN/IL1B)#Tcw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• absence of Il6 expression completely abolishes the metaplastic and dysplastic phenotypes seen in transgenic mice expressing Il6
• minor inflammatory response

immune system
• minor inflammatory response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT Barrett's esophagus DOID:9206 OMIM:614266
J:180282


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory