Phenotypes Associated with This Genotype

Genotype
MGI:5308954

• Allelic Composition: Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp; Kras^tm4Tyj/Kras⁺; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 7.2 weeks

• 60% of tumors exhibit anaplastic carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 40% of tumors exhibit well differentiated ductal adenocarcinoma histology

increased metastatic potential ( J:108298 )

• 20% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 7.2 weeks

• 60% of tumors exhibit anaplastic carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 40% of tumors exhibit well differentiated ductal adenocarcinoma histology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:108298