Phenotypes for Cdkn2a Kras Tg(Pdx1-cre)89.1Dam Trp53 MGI:5308962 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm2.1Rdp/Cdkn2a^tm2.1Rdp Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53⁺ Tg(Pdx1-cre)89.1Dam/0
Genetic Background	involves: 129 * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Rdp mutation (2 available); any Cdkn2a mutation (67 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 13.1 weeks

• 25% of tumors exhibit sarcomatoid carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 75% of tumors exhibit well differentiated ductal adenocarcinoma histology

increased metastatic potential ( J:108298 )

• 25% of tumors exhibit metastasis

endocrine/exocrine glands

increased pancreas tumor incidence ( J:108298 )

• mutants develop pancreatic tumors with an average latency of 13.1 weeks

• 25% of tumors exhibit sarcomatoid carcinoma histology

increased pancreatic ductal adenocarcinoma incidence ( J:108298 )

• 75% of tumors exhibit well differentiated ductal adenocarcinoma histology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:108298

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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