Analysis Tools
mortality/aging
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• 50% of mice die by 16 weeks of age
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behavior/neurological
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• mice exhibit RTT-like symptoms after 5 weeks of age
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• impaired motor learning on a rotarod
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• in an elevated zero maze
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• at 13 weeks of age
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• on a rotarod
• not as severe as in Mecp2tm1.1Jae hemizygotes
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• with splaying hind limbs upon movement
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• at 11, but not 3, weeks of age
• not as severe as in Mecp2tm1.1Jae hemizygotes
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nervous system
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• at P30 and P90
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• at P30, mice exhibit reduction in event-related power in delta, sigma and alpha low-frequencies compared with wild-type mice
• at P30, mice exhibit less of an increase in phase-locking factor at delta and high gamma frequencies compared with wild-type mice
• at P90, awake mice exhibit increased high-gamma frequency oscillation power compared with wild-type mice
• at P90, mice exhibit an increase in latency of P1, N1 and P2 peaks and reduction in the amplitudes of the N1 and P2 peaks of event-related potential compared with wild-type mice
• at P90, mice exhibit attenuated event-related power in both low- and high-frequency oscillation compared with wild-type mice
• at P90, mice exhibit less of an increase in phase-locking factor at all frequencies compared with wild-type mice
• however, mice exhibit normal power and event-related potential at P30
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growth/size/body
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• between 4 and 8 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:181311 | |
