Phenotypes Associated with This Genotype

Genotype
MGI:5313323

• Allelic Composition: Dnah5^b2b1003Clo/Dnah5^b2b1003Clo
• Genetic Background: C57BL/6J-Dnah5^b2b1003Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1003-004-LA exhibits heterotaxy indicated by levocardia and dextrogastria

growth/size/body

kidney cyst ( J:175213 )

• glomerular cysts

abdominal situs ambiguus ( J:175213 )

• abdominal heterotaxy

situs inversus totalis ( J:175213 )

renal/urinary system

abnormal kidney morphology ( J:175213 )

• duplicated left kidney

kidney cyst ( J:175213 )

• glomerular cysts

renal hypoplasia ( J:175213 )

• left kidney hypoplasia

duplex kidney ( J:175213 )

respiratory system

immotile respiratory cilia ( J:175213 )

• immotile tracheal airway cilia

cellular

immotile respiratory cilia ( J:175213 )

• immotile tracheal airway cilia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kartagener syndrome		DOID:0050144		J:175213
primary ciliary dyskinesia 3		DOID:0110599	OMIM:608644	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213