Phenotypes Associated with This Genotype

Genotype
MGI:5313510

• Allelic Composition: Tg(CRYBB1-CRYGC*)#Jfhe/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens fiber morphology ( J:181433 )

• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells

• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae

• the fiber cell migration and elongation patter is defective at the equatorial region

nuclear cataract ( J:181433 )

• mutants exhibit nuclear cataracts of varying severities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 2 multiple types		DOID:0110235	OMIM:604307	J:181433