Phenotypes Associated with This Genotype

Genotype
MGI:5314016

• Allelic Composition: Dnah5^b2b1134Clo/Dnah5^b2b1134Clo
• Genetic Background: C57BL/6J-Dnah5^b2b1134Clo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mutant 1134-007-MLC exhibits heterotaxy indicated by dextrocardia, lung lobation inversion, left liver isomerism and dextrogastria

growth/size/body

heterotaxia ( J:175213 )

situs inversus totalis ( J:175213 )

respiratory system

immotile respiratory cilia ( J:175213 )

• immotile airway cilia

cardiovascular system

abnormal cardiovascular system physiology ( J:175213 )

• congenital heart disease

cellular

immotile respiratory cilia ( J:175213 )

• immotile airway cilia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kartagener syndrome		DOID:0050144		J:175213
primary ciliary dyskinesia 3		DOID:0110599	OMIM:608644	J:175213
visceral heterotaxy		DOID:0050545	OMIM:306955 OMIM:605376 OMIM:606325 OMIM:613751 OMIM:614779 OMIM:PS306955	J:175213