Phenotypes Associated with This Genotype

Genotype
MGI:5314411

• Allelic Composition: Tg(MECP2)1Hzo/0
• Genetic Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:181213 )

• mutants exhibit anxiety-like behavior in the elevated plus maze

• mutants spend less time in the lit compartment of the light/dark box compared to wild-type mice indicating anxiety-like behavior

abnormal response to novel object ( J:323615 )

• 70-day old mice show reduced curiosity in exploration of a novel object than wild-type mice

• treatment of mice with miR-592 increases curiosity in object exploration to wild-type levels

abnormal social investigation ( J:181213 )

• mutants are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition

• in the three-chamber test for sociability, mutants show a deficit in social approach behavior toward novel partner mice, without a deficit in interest toward a novel object or a deficit in activity or preference for either chamber

homeostasis/metabolism

abnormal corticosterone level ( J:181213 )

• stress-induced corticosterone levels are higher in mutants than wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
syndromic X-linked intellectual disability Lubs type		DOID:0060799	OMIM:300260	J:181213