Phenotypes Associated with This Genotype

Genotype
MGI:5314412

• Allelic Composition: Tg(MECP2)3Hzo/0
• Genetic Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:181213 )

• mutants exhibit anxiety-like behavior in the elevated plus maze

• mutants spend less time in the lit compartment of the light/dark box compared to wild-type mice indicating anxiety-like behavior

decreased locomotor activity ( J:181213 )

• mutants travel less than wild-type mice in the open field

abnormal social investigation ( J:181213 )

• mutants are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
syndromic X-linked intellectual disability Lubs type		DOID:0060799	OMIM:300260	J:181213